). In this sense, our group has reported that a chimeric salt of vanadium (decavanadate-metforminium) improves glucose tolerance, lipid proles, glycogen, and triglyc-eride contents in the liver, muscle, heart, and kidney in Based on the results obtained, it can be concluded that the issues related to the interactions of V with Mg (as one of the elements with antioxidant potential) are important not only for extending the knowledge of the mechanism of the effect of V on the organism. It has been suggested that the hepatotoxic, nephrotoxic [48,62,[68], [69], [70], [71]], cardiotoxic [72], genotoxic [73,74], neurotoxic [72,75,76], and carcinogenic [48,77] effects of this metal as well as inflammatory and fibrotic changes in the lungs [78] are associated with the pro-oxidative potential of V and its ability to intensify LPO (Fig. Aqueous Chemistry of the VanadiumIII (VIII) and the VIIIDipicolinate systems and a comparison of the effect of three oxidation states of vanadium compounds on diabetic hyperglycemia in rats. The https:// ensures that you are connecting to the In: Aureliano M., editor. 15 Metal interactions affecting the cell metabolism, action of organs and, consequently, the function of the entire organism is still an important issue in toxicology, pharmacology, and medicine. Based on available literature data cited in section 5.1 and other reports; after [33], **after [38], after [39], *after [40], ##after [41]. A decrease in INS-R was demonstrated in obese rats (fa/fa Zucker rats) receiving V in the form of an organic derivative BMOV for 6 weeks [230] and in hypertensive rats chronically treated with VOSO4 [209]. first ed. The anti-obesity effect of natural vanadium-containing Jeju grand water. Characterization and mode of action. Hasegawa Y., Morioka M., Hasegawa S., Matsumoto J., Kawano T., Kai Y., Tano S., Fukunaga K., Kuratsu J. Tsave O., Petanidis S., Kioseoglou E., Yavropoulou M.P., Yovos J.G., Anestakis D., Tsepa A., Salifoglou A. As emphasized by the authors, these results may be helpful in the therapeutic application of V compounds along with antioxidants as synergistic agents in order to reduce their potential toxicities in normal cells without affecting their antitumor activities in cancer cells. The most common adverse effect of oral NaVO3 was mild gastrointestinal intolerance. Das S., Chatterjee M., Janarthan M., Ramachandran H., Chatterjee M. Vanadium in cancer prevention. Part 2: Health Effects). Dubyak G.R., Kleinzeller A. 2018; Trevino et al. Halberstam M., Cohen N., Shlimovich P., Rossetti L., Shamoon H. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Zhang Y., Zhang Q., Feng C., Ren X., Li H., He K., Wang F., Zhou D., Lan Y. Hu M., Coetzee P.P. Lipoprotein lipase: structure, function, regulation, and role in disease. However, all V compounds/complexes (used in these studies) were mainly tested in different cell lines, not in vivo conditions (in an animal model). Reduced glucose-induced thermogenesis is present in noninsulin-dependent diabetes mellitus without obesity. John Wiley and Sons; New York, Chichester, Weinheim, Brisbane, Singapore, Toronto: 1998. pp. The site is secure. The effect of the three vanadium complexes investigated for comparison with metavanadate and ammonium decavanadate were selected based on their chemical and insulin-enhancing properties [3], [19], [33], [34].The stability of the vanadium compounds were studied using spectroscopic techniques as described in a recent paper [19].In the present study, the presence of the vanadate compounds or . Bijelic A., Aureliano M., Rompel A. 12). Contribution of obesity to insulin resistance in noninsulin-dependent diabetes mellitus. Interrelations between Essential Metal Ions and Human Diseases. In addition, vanadium as vanadyl may also have an anti-hypertensive effect, as demonstrated by studies conducted on spontaneously hypertensive rats (SHR) and in those with hypertension induced by a fructose-rich diet (FHR rats) receiving vanadyl sulfate (VOSO4) or bis(maltolato)oxavanadium(IV) (BMOV) [[208], [209], [210]]. Effects of insulin on body composition in patients with insulin-dependent and non-insulin-dependent diabetes. Accessibility 15). ). HHS Vulnerability Disclosure, Help Epub 2022 Jul 1. It has also been reported that V species can enter cells via membrane citrate transporters, the lactate transporter, and the organic anion transporter (Organic-AT) [101]. (Vanadium in the Environment. Correia I., Chorna I., Cavaco I., Roy S., Kuznetsov M.L., Ribeiro N., Justino G., Marques F., Santos-Silva T., Santos M.F.A., Santos H.M., Capelo J.L., Doutch J., Pessoa J.C. Interaction of [V. Harris W.R., Carrano C.J. Walter de Gruyter GmbH; Berlin/Boston: 2018. pp. Metallurgical Examination of a 3-1/4 Thick Armor Plate From a German PzKw V (Panther) Tank; pp. Catal A. Lipid peroxidation of membrane phospholipids generates hydroxyl-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Effect of bis(curcumino)oxovanadium complex on non-diabetic and streptozotocin-induced diabetic rats. Nauk. government site. Vanadium-containing steel (with high hardness, strength, elasticity, and abrasion resistance) has been widely used as spring steel, tool steel, and high-speed steel. Recently, protective action of pyruvate against V-induced oxidative stress and cytotoxicity has been demonstrated in Chinese hamster ovary (CHO-K1) cells [275]. The influence of sodium metavanadate on the process of diabetogenesis The ability of this metal to form organometallic compounds has contributed to the increase in the number of studies on the multidirectional biological activity of its various organic complexes in view of their application in medicine. Careers. Biometals. The toxicological potential of V and the mechanisms of its toxic action, which have not been sufficiently recognized yet, as well as key information about the essentiality of this metal, its physiological role, and metabolism with certain aspects on the timeline is collected as well. Yoffa W., Hurlich A. Watertown Arsenal Laboratory; 1945. 7). In 1996, Halberstam et al. Acta Protein Structure Molecular Enzymology. Based on available literature data cited in section 1.1. Snchez C., Torres M., Bermdez-Pea M.C., Aranda P., Montes-Bayn M., Sanz-Medel A., Llopis J. Bioavailability, tissue distribution and hypoglycaemic effect of vanadium in magnesium-deficient rats. In: Sigel A., Sigel H., Freisinger E., Sigel R.K.O., editors. Trends in vanadium neurotoxicity. Since that time, more reports have appeared about the effects of co-application of V with Cr(III) [59,[269], [270], [271], [272]] or Mg [[51], [52], [53], [54], [55], [56], [57], [58],63,259,260] to rats (Fig. Bethesda, MD 20894, Web Policies Changes in lung function after exposure to vanadium compounds in fuel oil ash. In the late 1990s, two reports described the effect of Se on V toxicity in different regions of the rat brain [267] and a synergistic interaction between V and Mg on glucose metabolism in diabetic rats [253]. Anicic N., Vukomanovic M., Suvorov D. Design of a multifunctional vanadium pentoxide/polymer biocomposite for implant-coating applications. Taking into account the clear interest in the anti-viral, anti-bacterial, anti-parasitic, anti-fungal, anti-cancer, anti-diabetic, anti-hypercholesterolemic, cardioprotective, and neuroprotective activity of V and in the possibility of using this element in the treatment of obesity, the present review focuses on mechanisms underlying the pharmacological potential of this metal and obstacles to use it as a metallopharmaceutical in the future. Assem F.L., Levy L.S. As far as the historical outline of interactions is concerned, in 1970, Hill and Matrone proposed the theory of mineral interactions (Fig. Meyerovitch J., Farfel Z., Sack J., Shechter Y. Thus, the toxicity of V that could derive from the chronic treatment with this element is of particular concern. However, although some studies cited above reveal that supplementation with Mg during V exposure has beneficial effects reflected in reduction of the level of LPO in certain cells/tissues of healthy rats, further studies (in other animal models) have to be conducted to recognize whether the antagonistic effects of Mg on pharmacological amounts of V will allow V to exert beneficial effects, or whether their synergistic actions yield beneficial effects at lower amounts of V. Some time ago, Matsuda et al. V: vanadium, DM: diabetes mellitus, GLU: glucose, INS: insulin, BEOV: bis(ethylmaltolato)oxovanadium(IV). : decrease. phosphate or sulfate channels [106]. 3 Al-Bayati M.A., Xie Y., Mohr F.C., Margolin S.B., Giri S.N. 11 Consequently, appetite, body fat mass, and body weight are reduced [221,223] (Fig. Mechanism of vanadate-induced contraction of airways smooth muscle of the guinea-pig. 91120. Additionally, Sanchez et al. Toxicol. Model studies related to vanadium biochemistry: recent advances and perspectives. In turn, higher concentrations of V in the soil lead to more intensive uptake of this metal being by plants due to the lack of a selective mechanism protecting plants against excessive absorption of the element. 11). Moreover, polymeric V-based coatings made of a (Poly)Lactide-co-Glycolide copolymer (PLGA) with antimicrobial activity (Table 2) [122] and a diamond-like layer including V (V-DLC) are also formed to be used as implant materials [11] (Table 2). Adriazola I.O., Evangelista do Amaral A., Amorim J.C., Correia B.L., Petkowicz C.L., Merc A.L., Noleto G.R. The research on the interactions of V with antioxidant elements has been gaining popularity since 2005. , the first report describing certain effects of V action in patients with diabetes mellitus (DM) appeared in 1899. Vanadium: Risks and possible benefits in the light of a comprehensive Nauk. 6). Part 2: Health Effects). Their experiments demonstrated that these complexes acted in an apoptotic mode and were non-toxic to the normal T293 cell line [166]. In: Michibata H., editor. Cohen N., Halberstam M., Shilimovich P., Chang C.J., Shamoon H., Rossetti L. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. MeSH Beyersmann D., Hartwig A. Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms. Vanadium speciation by chromatographic separation of V(IV) and V(V) in acidic solution followed by ICP-OES determination. 710/715, January. It can improve blood glucose levels and maintain them in the normal range. Goc A. It has been reported that V in the form of vanadyl (VO2+, tetravalent V4+ state) binds to Tf at the same binding site as the Fe3+ ion [97] and that V5+, for which the cationic form (dioxovanadium cation, VO2 The health effects of Vanadium are often utilized in supplements for diabetes, heart disease and cholesterol control. The other findings reported by cibior et al. FOIA Bookshelf 1991 Apr;72(4):801-7. doi: 10.1210/jcem-72-4-801. Effect of magnesium supplementation on oxidative stress in alloxanic diabetic rats. /HVO4 Besides the issues mentioned above and those presented in section 9 titled Vanadium - important research trends and the need to identify the susceptibility of different cells/tissues to the effects of V, the following aspects draw researchers' attention: (a) identification of V species as an important factor in the assessment of toxicity of this element and its potential health risks to humans [276] (Fig. 11), (c) potentiation of anti-proliferative activity [136], (d) inhibition of the activity of IB topoisomerase (Top-IB) [153] (Fig. Three Diseases For Which Sodium Metavanadate Is Used For Treatment Davis J.R. ASM International; 2003. Besides, other authors described the use of V in diabetes mellitus (DM) (Fig. Would you like email updates of new search results? 31. A review of thirty years of research. Journal of Trace Elements in Medicine and Biology, PzKw V (Panther) tank (Panzerkampfwagen V Panter), Components parts for weapons and aircraft (engine parts, fasteners), Component parts for aircraft (pipes in hydraulic systems), Component parts for aircraft (compressor blades), Component parts for aircraft (jet engines), rocket engine housings, weapon components, Component parts for aircraft (landing gear, parts responsible for take-off and landing), Component parts for aircraft (hulls, wires), Biocompatible coatings applied on metallic alloys.

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